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KMID : 1007420150130010036
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Mood and Emotion
2015 Volume.13 No. 1 p.36 ~ p.38
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Secondary Mania as an Initial Manifestation of Metronidazole-Induced Encephalopathy in a Patient with Liver Cirrhosis
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Oh Hyung-Geun
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Abstract
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Although mania is commonly associated with bipolar disorder, it can have many etiologies. Secondary mania results from pharmacological, metabolic, or neurologic causes. Mania as adverse effects of antibiotics such as metronidazole is infrequent. We report a 51-year-old man with liver cirrhosis but no past history of psychiatric illness, who developed mania after receiving metronidazole. Brain magnetic resonance imaging (MRI) showed characteristic lesions which indicated metronidazole-induced encephalopathy. After stopping metronidazole, his manic symptom disappeared. Neuroimaging examination suggests that our patient’s manic symptom was ascribable to damage to the rostral brainstem monoaminergic nuclei and its projections to the frontal-subcortical circuit components.
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KEYWORD
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Mania, Metronidazole, Encephalopathy
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